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Methamphetamine use was found to be related to higher frequencies of unprotected sexual intercourse in both HIV-positive and unknown casual partners, an association more pronounced in HIV-positive participants.These findings suggest that methamphetamine use and engagement in unprotected anal intercourse are co-occurring risk behaviors, behaviors that potentially heighten the risk of HIV transmission among gay and bisexual men.Methamphetamine is known to possess a high addiction liability (i.e., a high likelihood that long-term or high dose use will lead to compulsive drug use) and high dependence liability (i.e.

Levomethamphetamine is available as an over-the-counter (OTC) drug for use as an inhaled nasal decongestant in the United States.

Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms.

It is rarely prescribed due to concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy.

The FDA also advises individuals with bipolar disorder, depression, elevated blood pressure, liver or kidney problems, mania, psychosis, Raynaud's phenomenon, seizures, thyroid problems, tics, or Tourette syndrome to monitor their symptoms while taking methamphetamine.

The physical effects of methamphetamine can include loss of appetite; hyperactivity; dilated pupils ( Mydriasis ); excessive sweating; increased movement; dry mouth and teeth grinding (leading to "meth mouth"); headache; irregular heartbeat (usually as accelerated heartbeat or slowed heartbeat); rapid breathing; high blood pressure or low blood pressure; high body temperature; diarrhea or constipation; blurred vision; dizziness; twitching; muscle cramps, spasms, pain or stiffness; numbness; tremors; dry skin; acne; and pale appearance or flushed skin.

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